Protein Crystallography in Drug Discovery PDF
By:Robert E. Babine,Sherin S. Abdel-Meguid,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Published on 2004-02-13 by John Wiley & Sons
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
This Book was ranked at 16 by Google Books for keyword Crystallography.
Book ID of Protein Crystallography in Drug Discovery's Books is 5wdG6yeF9JAC, Book which was written byRobert E. Babine,Sherin S. Abdel-Meguid,Raimund Mannhold,Hugo Kubinyi,Gerd Folkershave ETAG "w2pInGemLMg"
Book which was published by John Wiley & Sons since 2004-02-13 have ISBNs, ISBN 13 Code is 9783527306787 and ISBN 10 Code is 3527306781
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